TMEM38A and facioscapulohumeral muscular dystrophy: While this is difficult to filter out in multifactorial disease, there is clear evidence of this being true as genes that have been shown under the control of the muscle-specific NETs PLPP7 and TMEM38a (in mouse myotubes53) are also misregulated in FSHD, where the expression of PLPP7 and TMEM38A appears to be correlated to disease severity.