While this is difficult to filter out in multifactorial disease, there is clear evidence of this being true as genes that have been shown under the control of the muscle-specific NETs PLPP7 and TMEM38a (in mouse myotubes53) are also misregulated in FSHD, where the expression of PLPP7 and TMEM38A appears to be correlated to disease severity. Here, PLPP7 is linked to facioscapulohumeral muscular dystrophy.