Furthermore, activation of GPR55 using O-1602 increased levels of Nrf2-regulated anti-oxidative enzymes, such as SOD, GSH, and catalase, while it decreased levels of malondialdehyde, another lipid peroxidation marker, in β-amyloid [84] and streptozotocin [85] induced AD mice model. Here, GPR55 is linked to Alzheimer disease.