Compared to samples with low DHODH expression (Supplementary Fig. 3B), those with high DHODH expression (Supplementary Fig. 3C) had lower scores for the release of cancer antigen (step 1), cancer antigen presentation (step 2), priming and activation (step 3), trafficking of immune cells to tumors (step 4), T cell infiltration (step 5), and recognition of cancer cells by T cells (step 6) (Supplementary Fig. 3A–C). The gene discussed is DHODH; the disease is cancer.