SHBG and coronary artery disorder: The IVW method reveals that with each increase of 1-SD in SHBG, the reduction in CHD risk is greater in the females (OR 0.71; 95% CI 0.61–0.82; p-value = 8.23 × 10–6) compared to the males (OR 0.78; 95% CI 0.66–0.92; p-value = 3.37 × 10–3), and the significance of this association is also greater in females than in males (Fig. 7).