Furthermore, the IVW method also indicates that each increase of 1-SD in SHBG is associated with a reduced risk of high cholesterol (OR 0.72; 95% CI 0.64–0.82), hypercholesterolemia (OR 0.71; 95% CI 0.61–0.82), and CHD (OR 0.73; 95% CI 0.63–0.86) (Fig. 4). This evidence concerns the gene SHBG and familial hypercholesterolemia.