SHBG and hypertensive disorder: The IVW method indicates that each increase of one-standard-deviation (1-SD) in SHBG is associated with a reduced risk of CHD (OR 0.73; 95% CI 0.63–0.86), MI (OR 0.77; 95% CI 0.66–0.90), and hypertension (OR 0.84; 95% CI 0.74–0.96), but not with the other two CVDs (Fig. 2).