Among them, CDH1 (encoding E-cadherin) [2] and CTNNA1 (encoding α-E-catenin) [2, 3], and APC promoter 1B pathogenic variants [4], have been related to hereditary syndromes with high risk mainly of GC (hereditary diffuse GC syndrome, or HDGC, and gastric adenocarcinoma and proximal polyposis of the stomach, respectively). The gene discussed is CDH1; the disease is gastric adenocarcinoma.