In addition to ER stress, other forms of proteotoxic stress such as mitochondrial stress, oxidative stress, the ubiquitin–proteasome system (UPS), the autophagy-lysosome pathway, and stress affecting organelles like the Golgi apparatus and lysosomes could potentially contribute to the pathobiology of BAG5-related cardiomyopathy. Here, BAG5 is linked to cardiomyopathy.