BAG5 and familial dilated cardiomyopathy: In this study, a novel homozygous 2-bp deletion variant c.444_445delGA (p.Lys149AsnfsTer6) in BAG5 associated with familial DCM adds to the growing list of pathogenic variants within BAG5 gene associated with DCM, underscoring the genetic heterogeneity of this condition, and suggesting that these BAG5 mutations are loss-of-function variants.