ATP1A3 and perinatal asphyxia: Further investigation is now necessary to identify additional molecular signaling pathways specifically activated downstream of ATP1a3, but the important role of ATP1a3 in neuronal autophagy and autosis demonstrated in the present study paves the way for developing new neuroprotective strategies targeting ATP1a3-dependent autosis pathways specifically in neurons that could be potentially used in many neurological disorders including HIE.