MAPT and Alzheimer disease: Finally, the majority (14/17) of included postmortem studies were completed between 1990 and 2000, and before the publication of the National Institute for Ageing and the Alzheimer’s Association research framework which defined in vivo biological criteria for AD, which included measures of aggregated Aβ and tau in the CSF.51 Thus, the AD pathological assessments reported in the included studies do not fully align with current AD diagnostic criteria.