<h4>Objective</h4>This study aimed to investigate the impact of Dickkopf 2 (DKK2) on the progression of oral squamous cell carcinoma (OSCC) and explore its role in the PI3K/AKT signaling transduction pathway.<h4>Materials and methods</h4>The study initially examined the expression of the DKK2 gene in OSCC tissues and normal tissues. Here, DKK2 is linked to oral cavity squamous cell carcinoma.