CYP3A4 and nephrotic syndrome: Sensitivity 80%-95% (85, 86)Specificity 80%-95% (dependent on cut-off value) (85, 86)Affected by dexamethasone clearance and metabolism—including medications affecting CYP3A4 complex, eg, rifampicin (87)Affected by changes in CBG, eg, use of oral estrogens (increasing CBG) and nephrotic syndrome/cirrhosis (reducing CBG) (14)