Notably, after successful surgical treatment of CS, FKBP5 mRNA expression decreased to levels similar to those of HCs (CS postsurgery 1148.7 ± 372.8, HCs 918.7 ± 311.1) but remained elevated in patients with failed surgical treatment (2505.3 ± 1843.4) (257). Here, FKBP5 is linked to Cowden syndrome 1.