Potential biomarker of cortisol activity at the GR (257, 258)Reduces GR activity through reduced cortisol binding affinity (259)Increased levels following infusion of hydrocortisone and dose of prednisone (260, 261)Increased levels in ACTH-dependent CS compared with controls (with normalization following curative surgery) (257)Reduced levels with GC antagonist (261). Here, NR3C1 is linked to Cowden syndrome 1.