PRSS1 and hereditary chronic pancreatitis: Genes associated with increased PC risk include hereditary breast cancer genes (BRCA1, BRCA2, ATM, and PALB2), CDKN2A (familial atypical multiple mole-melanoma syndrome - FAMMM), Lynch syndrome genes (MLH1, MSH2/EPCAM, MSH6), STK11 (Peutz-Jeghers syndrome), TP53 (Li-Fraumeni syndrome), and hereditary pancreatitis genes such as PRSS1 [4].