More importantly, UBE2L3 acted as a Hub gene, demonstrated potential predictive ability for efficacy in AD treatment [35], UBE2L3 Reduces E3 Ubiquitin-protein ligase TRIM21 expression and IL-1β secretion in epidermal keratinocytes and improves psoriasis-like skin, indicated that UBE2L3 may be a protective biomarker in the epidermis of psoriasis [36]. Here, TRIM21 is linked to Alzheimer disease.