In addition, in this case, AMG+ patients had significant alterations in lipid metabolism such as hypertriglyceridemia (at T6 p = 0.001 and T12 p = 0.006) and a reduction in HDL at T12 (p = 0.024) as well as significantly worse renal function parameters, both in terms of serum creatinine (at T1 p = 0.015 and T12 p = 0.001) and in terms of eGFR (at T1 p = 0.004, at T6 p = 0.002, at T12 p = 0.004) (Figure 4 and Table S5). The gene discussed is AMELX; the disease is hypertriglyceridemia.