UCP1 and obesity due to melanocortin 4 receptor deficiency: Ginsenoside Rg1 can improve gut microbiota disorders in mice caused by feeding high-fat diets, increase the relative abundance of Lachnoclostridium, Streptococcus, Lactococcus, Enterococcus, and Erysipelatoclostridium, increase the levels of CA and TCA significantly in bile acids, decrease TC and TG levels, increase UCP-1 expression in brown adipose tissue, and increase adipose thermogenesis to ameliorate obesity [109].