AKT1 and Insulin resistance: Saponins are mainly used to reduce blood glucose by promoting insulin secretion, improving insulin resistance, etc. Ginsenoside Rk3 reduced serum insulin levels to promote insulin secretion through the AMPK/Akt signaling pathway, improved glucose tolerance and insulin resistance, and significantly lowered blood glucose levels in diabetic mice induced by a high-fat diet/streptozotocin [20].