In addition, ginsenosides Rg3 and Rb1 increased the expression of browning-related genes, such as brown adipose-specific uncoupling protein 1 (UCP1), by increasing the phosphorylation of AMPK and regulating the expression of PPAR-γ in 3T3-L1 cells, respectively, and it induces the browning of white adipocytes and reduces the deposition of lipid droplets in the cells, which is an anti-obesity effect [58,59]. The gene discussed is UCP1; the disease is obesity due to melanocortin 4 receptor deficiency.