NFKB1 and chronic obstructive pulmonary disease: Our findings show a significant reduction in the in vivo effect of Lr on the total cell numbers (Figure 11A) and macrophage population (Figure 11B) in BALF, as well as ROS (Figure 11C) concentration and NF-κB (Figure 11D) mRNA expression in lungs from COPD mice treated with GLPG-094 compared with the COPD group.