In a different way, Figure 8 illustrates that COPD mice had a significant reduction in anti-oxidant agents SOD (Figure 8A), catalase (Figure 8B), and HO-1 (Figure 8C) as well as mRNA expression to Nrf2 (Figure 8D) in lung tissue compared to the control group. The gene discussed is HMOX1; the disease is chronic obstructive pulmonary disease.