Moreover, there was a significant reduction in Lr ability in restoring the balance of oxidative stress, i.e., Lr decreases ROS, isoprostane, NADPH oxidase, and TBARS, while it slightly increases SOD, catalase, and HO-1, and upregulates Nrf2 in the lungs of COPD mice treated with GLPG-094. Here, NFE2L2 is linked to chronic obstructive pulmonary disease.