FMO5 and chronic obstructive pulmonary disease: Whereas corticoid therapy was not effective to attenuate the lung inflammation as well as airway remodeling in COPD mice, and NADPH oxidase is not a molecular target of corticoids, it is reasonable to suggest that Lr presents a wider effect compared to dexamethasone, and maybe for this reason had a beneficial effect in a corticoid-resistance pro-inflammatory condition.