To explore whether Lr could impact the imbalance between pro- and anti-oxidant agents in COPD mice, we assessed the effect of Lr on secretion of pro-oxidant agents ROS, 8-isoprostane (8-Iso), TBARS, and NADPH oxidase as well as the Lr effect on anti-oxidant agents SOD, catalase, HO-1, and Nrf2 expression. This evidence concerns the gene HMOX1 and chronic obstructive pulmonary disease.