Furthermore, the mentioned effects in CerS expression, especially decreased in the ceramide synthase 6 (CerS6) expression after α-LA supplementation, are most consistent with the available data indicating that CerS6 deficiency in mice model decreased the C16 ceramide content, protecting from glucose intolerance and obesity induced by an HFD [24]. The gene discussed is CERS6; the disease is obesity due to melanocortin 4 receptor deficiency.