On the other hand, our lab and others, in part through comprehensive flow cytometry panels, have demonstrated that CD4+ T-cells and effector CD4+ T-cells (Teff) subsets are similarly frequent in peripheral blood from T2D compared to obesity plus normal glucose tolerance (ObNGT) subjects, despite higher production of Th1 and/or Th17 signature cytokines [18,20,27]. This evidence concerns the gene CD4 and obesity disorder.