CREB1 and major depressive disorder: However, Limk1 silencing can be relieved by the administration of BDNF, indicating a role of anti-inflammatory factors on the dendrite size [31]; miR-134 has also been confirmed to downregulate a related neurotropic factor, cerebral dopamine neurotrophic factor (CDNF) [36], as well as BDNF itself and cAMP-response-element binding protein (CREB-1) [35]; (2) miR132, found in the brain and other tissues [38], upregulates glutamate receptors [37], and is repressed by the downregulation of BDNF, with both implicated in disorders such as ASD and depression [37].