Animals treated with the alkaloid extract (10 or 20 mg/kg bw) between the 37th and 41st day of infection showed an increased number of macrophages, elevated NO and IFN-γ concentrations, and reduced number of eggs and granulomas in the liver.Animals treated with the alkaloid extract between the 45th and 49th day of infection showed a reduced number of eggs (10 or 20 mg/kg bw) and granulomas (10–40 mg/kg bw) in the liver. This evidence concerns the gene IFNG and Granuloma.