Lastly, cabazitaxel-loaded human serum albumin nanoparticles combined with transforming growth factor beta-1 siRNA lipid nanoparticles (CTX-HSA-NPs and TGFβ-1 siRNA LNP) were developed specifically for the treatment of paclitaxel-resistant non-small cell lung cancer. The gene discussed is TGFB1; the disease is non-small cell lung carcinoma.