Similarly, another lipid nanoparticle (LNP) encapsulating glutathione S-transferase P (GSTP) siRNA targeting Kirsten rat sarcoma virus (KRAS)-driven non-small cell lung cancer (NSCLC) was investigated for its biodistribution, antitumor activities in Kirsten rat sarcoma virus (KRAS) mutant NSCLC xenograft models, and survival in orthotopic lung tumor models. The gene discussed is GSTP1; the disease is non-small cell lung carcinoma.