These include inhibition of tyrosine kinase and DNA topoisomerase, angiogenesis, antioxidant effects, risk reduction of various cancers, activation of insulin-like growth factor-I (IGF-1) and serotonergic receptors, interacting with cAMP/protein kinase A, cGMP/nitric oxide (NO), phosphatidylinositol-3 kinase/Akt and MAP (ERK1,2, p38) kinases and transcription factors (including NF-kB), influencing RNA expression, DNA methylation, cell cycle and apoptosis regulators and histone modifications [16,17]. Here, IGF1 is linked to cancer.