ESR2 and colorectal carcinoma: These data collectively demonstrate that phytoestrogens have a higher affinity for ER-β, and since ER-β has been shown to play an important role in the development of adenomatous polyps and in the early stages of CRC carcinogenesis, the efficacy of selective agonists for this receptor subtype in the chemoprevention of FAP and CRC was investigated [23,24].