The similar mechanism of chemoresistance development was demonstrated in work [53]: treatment of gastric cancer with 5-fluoruracil (5-FU) was associated with activation of HIF1α signaling and expression of damage-associated molecular patterns, HMGB1, in tumor cells, which, in turn, enhanced macrophage recruiting and their polarization towards M2. The gene discussed is HIF1A; the disease is neoplasm.