Extracellular vesicles, isolated from glioma cells in hypoxic conditions, contained high levels of IL-6 and miR155-3p, promoting M2 macrophage polarization via the IL-6-pSTAT3-miR-155-3p-autophagy-pSTAT3 pathway and, consequently, glioma progression [21]. Here, IL6 is linked to central nervous system cancer.