Gold core NPs, covered with thiolated PEG-COOH polymer, thiolated anti-VEGF siRNA, and M2 peptide, targeting the M2 MARCO scavenger receptor, were instilled intratracheally to mice resulting in efficient decrease in VEGF expression level in lungs and ~95% reduction of TAMs that mediated a delay in lung cancer progression and survival increase [9]. This evidence concerns the gene VEGFA and lung carcinoma.