These nanoparticles, comprising rare-earth-upconversion-nanoparticle-based photosensitizer NaYF4:Yb,Er@NaYF4, covered with TAM-derived membrane, possess antigen-homing affinity capacity and immune compatibility, contributing to the depletion of CSF1 secreted by tumor cells and blockade of the interaction between TAMs and cancer cells [108]. The gene discussed is CSF1; the disease is neoplasm.