Dysregulated inflammasome activity is associated with intermittent inflammatory and autoimmune responses, which leads to multiple autoimmune diseases and complex syndromes, including gout, type 2 diabetes, rheumatoid arthritis (RA), and inflammatory bowel disease (IBD); therefore, their regulation permits maintaining immune system homeostasis since, for example, an important consequence of the activation of NLRP3 (Figure 1) increases the levels of the inflammatory cytokines IL-1β and IL-18 [2,3,4]. The gene discussed is IL1B; the disease is rheumatoid arthritis.