Previously, Lin et al. [7] showed that the recombinant polypeptide of HGFK1 (rHGFK1) inhibited the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aortic endothelial cells and suppressed tumor growth and metastasis by inhibiting tumor neovascularization in an established rat orthotopic hepatocellular carcinoma (HCC) model. This evidence concerns the gene FGF2 and neoplasm.