SIRT1 and posterior cortical atrophy: By promoting miR-138-5p targeting to its 3’UTR region, APS inhibited the expression of SIRT-1 and SREBP-1, promoted signaling in the miR-138-5p/ SIRT-1/SREBP-1 pathway in PCa and DU145 cells, and suppressed tumorigenesis and lipid metabolism [121].