For example, a traditional Chinese medicine blend known as Bu Zhong Yi Qi Tang (BYD), which contains APS as a key ingredient, effectively reduced PD-L1 expression in gastric cancer tissues and targeted PD-1 and PD-L1 within tumors through the PI3K/Akt/mTOR pathway, resulting in significant suppression [136]. This evidence concerns the gene AKT1 and gastric cancer.