During the investigation into APS and Shenqi Fuzheng Injection (composed mainly of Radix et Rhizome Ginseng and Radix Astragali) for treating gastrointestinal diseases, APS not only slowed pancreatic tumor growth but also reduced tumor-associated fibroblasts’ ability to secrete βig-H3, thereby promoting the expansion of CD8+ T cells and inhibiting the transition of macrophages to the M2 type, and consequently enhancing the pancreatic tumor’s sensitivity to gemcitabine and other therapies. The gene discussed is TGFBI; the disease is pancreatic neoplasm.