Through overlapping the top 15 genes with values of degree, betweenness and closeness via a Venn diagram, the genes JUN, CCL5, ACE, PDGFRB, C3, HSPG2, FBN1, LRP1, PDGFB and HIST1H2AC were identified as hub genes, which might play an important role in anti-erythroleukemia of BW18 (Supplementary Table S2). The gene discussed is H2AC6; the disease is erythroleukemia.