The scaffold hopping strategy was also useful for the discovery of some hybrids bearing 1H-indazol-3-amine and benzohydroxamic acids with dual HDAC/EGFR1 inhibitory activity against breast cancer line MCF-7 [216], and of a novel Aminotetralin Class of HDAC6 and HDAC8 selective inhibitors with potent inhibitory activity against neuroblastoma BE(2)C cells [217]. This evidence concerns the gene HDAC9 and breast carcinoma.