Co-immunoprecipitation (coIP) analysis demonstrated an interaction between EZH2 and HDAC2 in ARID1A-mutated Ovarian Tumor-derived Cell Line 21G (TOV21G), and the restoration of wild-type ARID1A disrupted this interaction, suggesting that EZH2 did not interact with HDAC2 in ARID1A wild-type cells. This evidence concerns the gene ARID1A and ovarian neoplasm.