Angiopep-2 (TFFYGGSRGKRNNFKTEEY) targets low-density lipoprotein receptor-related protein 1 (LRP-1) that is overexpressed by both endothelial cells of the BBB and glioma cells and has been used to coat hyaluronic acid NPs to enhance delivery to human glioblastoma cells [81]. This evidence concerns the gene LRP1 and central nervous system cancer.