CXCR4 and neoplasm: In addition, the formation of mitochondria-dependent vital NETs by silent information regulator 1 (SIRT1) that has been reported in both tumour-associated aged neutrophils (Naged, CXCR4+ CD62L low) in breast cancer lung metastasis [53] and non-tumour pathologies [54] has not been studied in preeclampsia.