With derived deoxycholic acid, Clostridium scindens targets the cell membrane calcium pump plasma membrane Ca2+ATPase (PMCA) to promote Ca2+ efflux, which leads to a reduction in intracellular Ca2+ and inhibition of NFAT2, thus decreasing the anti-cancer function of effector CD8+T-cells [80], which ultimately promotes cancer immune escape. This evidence concerns the gene CD8A and cancer.