Finally, a 1 g daily dose of resveratrol for 3 months [369] also showed effectiveness in reducing joint swelling and tenderness, as well as TNF-α, IL-6, protein C-reactive, MMP-3, the erythrocyte sedimentation rate, and undercarboxylated osteocalcin in patients with RA of both genders [369]. This evidence concerns the gene IL6 and rheumatoid arthritis.