On the other hand, 750 mg/kg Opuntia monacantha showed effectiveness in reducing paw edema, the arthritic score, the rheumatoid factor, inflammation, COX-2, IL-6, TNF-α, IL-1, NF-κB, bone erosion, and pannus formation, restoring hemoglobin, white blood count, and platelet parameters, increasing catalase and superoxide dismutase levels, and enhancing IL-4 and IL-10, namely, by its potential to inhibit glutaminase 1 activity in a RA rat model [361]. This evidence concerns the gene TNF and rheumatoid arthritis.