Moreover, 100 and 200 mg/kg extra virgin olive oil showed the capability to decrease inflammatory markers, joint edema, cell migration, cartilage degradation, and bone erosion in a collagen-induced arthritis model mice, namely, by inhibiting c-Jun N-terminal kinase, p38, signal transducer, and activator of transcription-3, as well as reducing COX-2 and microsomal prostaglandin E synthase-1 expression [353]. Here, MAPK1 is linked to arthritic joint disease.