In addition, at 12.5–50 μM, this compound also showed capacity to reduce IL-1β, PMA-induced IL-6, and VEGF-A expression by inhibiting NF-κB and induce dephosphorylation of ERK1/2 and enhance apoptosis in both in MH7A cells and RA-fibroblast-like synoviocytes [286]. The gene discussed is IL1B; the disease is rheumatoid arthritis.