CASP3 and rheumatoid arthritis: Moreover, 100 and 200 μM resveratrol also showed the ability to reduce the viability of human RA synovial MH7A cells by stimulating H2A.X phosphorylation and consequent apoptosis events, disrupt mitochondrial membrane potentials and stimulat cytochrome c release from the mitochondria to the cytosol, activate caspase-3 and caspase-9 but not caspase-8, upregulate the expression of the NAD-dependent deacetylase sirtuin (SIRT) 1 mRNA and downregulate the expression of the Bcl-X(L) mRNA, hence suppressing synovial cells hyperplasia [299].