Furthermore, 25 mg/kg of this compound can also decrease articular edema, NF-κB, and neutrophil elastase, and hence, diminish neutrophil extracellular traps, in RA rats, namely, by interfering with TLR-4, peptidyl arginine deiminase 4 enzyme and COX-2 [336]. Here, NFKB1 is linked to rheumatoid arthritis.