STAT3 and rheumatoid arthritis: Particularly, curcumin displayed the capability to relieve rheumatoid arthritis progression by suppressing inflammatory responses, synovial hyperplasia, and protein expression levels of phosphorylated JAK2 and STAT3 in mice with the collagen-induced arthritis model that were treated at a dose of 100 μM curcumin/day for almost three months [29], while in docking studies, salvianolic acid C exhibited a great binding affinity for JAK (10.7 kcal/mol) [24].