On the other hand, a dose of 100 μM resveratrol reduces the expression of MMP-1, MMP-3, MMP-9, RANKL, osteoprotegrin [302], and TNF-α by interfering with the sirtuin1/cortistatin pathway [303], as well as increasing the expression of genes involved in mitosis, the cell cycle, chromosome segregation, and apoptosis in RA fibroblast-like synoviocytes [304]. This evidence concerns the gene MMP3 and rheumatoid arthritis.