On the other hand, 0.1 and 1 μM gallic acid increase caspase-3 activity, regulate Bcl-2, Bax, p53, and pAkt production and reduce IL-1β, IL-6, CCL-2/MCP-1, CCL-7/MCP-3, COX-2, and MMP-9 on fibroblast-like synoviocytes from patients with RA [311]. Here, CCL2 is linked to rheumatoid arthritis.