Protect articular cartilage↓ Synovitis, IL-1β, MCP1, MIP1α, MMP1 and MPP3, and RANKL expressionRepress TNF-induced formation of osteoclasts and mRNA levels of cathepsin K and MMP9Inhibition of NFATc1 expression and NF-κB activation. This evidence concerns the gene CTSK and synovitis.