NOS2 and rheumatoid arthritis: Finally, the liposomal drug delivery system for morin, a dietary polyphenol, showed the capacity to ameliorate RA in rats, mainly by increasing its uptake by synovial and spleen macrophages, reducing mRNA expression and consequent production of TNF-α, IL-1β, IL-6, IL-17, RANKL, STAT-3, p-STAT-3, VEGF, iNOS, and NF-κB-p65, and increasing the expression of osteoprotegerin [235].