On the other hand, Li et al. [298] reported that 50 μM resveratrol can block fibroblast-like synoviocytes in RA cells at the G2/M stage and reduce TNF-α levels and the S phase cell ratio by promoting the serine–threonine kinase-p53 axis, and autophagy, which, subsequently, leads to cells apoptosis. This evidence concerns the gene TNF and rheumatoid arthritis.