Suppress the progression and development of RA↓ Arthritis severity scores, paw swelling and joint destruction, IL-6 and TNF-α amounts and excised phosphorylated (p)-p38 and p-p65, phosphorylated-c-JUN N-terminal kinase, and phosphorylated NF-κB and inhibitor alpha. This evidence concerns the gene MAPK1 and Arthritis.