In addition, at 12.5–50 μM, this compound also showed capacity to reduce IL-1β, PMA-induced IL-6, and VEGF-A expression by inhibiting NF-κB and induce dephosphorylation of ERK1/2 and enhance apoptosis in both in MH7A cells and RA-fibroblast-like synoviocytes [286]. This evidence concerns the gene NFKB1 and rheumatoid arthritis.