Enrichment analysis of the single-gene GSEA-KEGG pathway (Figure 5) found that AURKA and S1PR1 are all involved in DNA replication signals and can affect the cytochrome P450 enzyme system in drug metabolism, which suggests that hub genes affect tumour progression during the DNA replication phase of tumour cell growth while also having the potential for involvement in tumour drug resistance. The gene discussed is S1PR1; the disease is neoplasm.