NOTCH1 and neoplasm: Firstly, in the context of endothelial cells, it has been reported that the downregulation of NOTCH2 in a hypoxic environment can promote pro-tumor properties, such as migration or proliferation, mainly guided by the increase of NOTCH1 (as a compensatory mechanism for the decrease in NOTCH2) that is related to GSCs, as well as glioblastoma malignancy [41,42].