Fifthly, nsp5 impairs porcine DNA polymerase delta interacting protein 3 (POLDIP3)-mediated antiviral effects by cleaving POLDIP3 at Q176 via its 3C-like protease activity in a manner independent of the proteasome and cellular autophagy pathways, ensuring efficient PEDV infection [93]. The gene discussed is POLDIP3; the disease is infection.