HAVCR2 and neoplasm: Of note, we and others have shown that multiple tumors induce up-regulation/activation of β-catenin in DCs, including tumor-infiltrated DCs to restrain anti-tumor CD8 T cell responses [20,21,23,24], raising the intriguing scenario that tumors might exploit the β-catenin/Tim-3 pathway in DCs to suppress anti-tumor CD8 T cell immunity.