CD274 and infection: To test for (i) a direct correlation between improved T cell functionality and splenic virus load control and (ii) the maintenance of the LCMV-specific CD8 T cell response after immunotherapy, chronic infected mice were treated with anti-PD-L1 (Figure 2a) and analyzed 30 days after treatment (day 60 post-infection) for specific CD8 T cell responses (Figure 2b), virus loads (Figure 2c) and fibrosis score (Figure 2d).