While it is known that ACE2 is involved in infection, many studies have shown that SARS-CoV-2 has features of receptor promiscuity that allow it to bind and infect using other receptors including neuropilin-1 [24,48,49], and alternate hypothesized receptors include Basigin [50], ASGR1, KREMEN1 [51], CD209 [52] and DPP4 (the primary receptor for MERS-CoV) [25,53]. This evidence concerns the gene ACE2 and infection.