MYC and cancer: Beyond that, T-VEC (like its parental wild-type HSV-1 virus) can alter signaling pathways and regulatory networks in cancer cells, which could affect the expression of Myc: HSV-1 is known to use viral proteins such as virion protein 16 (VP16) or infected cell protein 0 (ICP0) for its replication, which are associated with general transcription factors and chromatin-modifying coactivators, thus potentially influencing Myc promoters and modulating their activity for this purpose [46,47,48,49].