IFITM3 and viral infectious disease: Using these mouse models, IFITM3 was shown to prevent severe pathology upon virus infections in mice, including SARS-CoV-2 [54], IAV (H1N1 and H3N2) [55,56], WNV [57], CHIKV, Venezuelan equine encephalitis virus [58], RSV [59], and CMV [60].