Hence, in this study we first focused on addressing this question by compiling known dengue-specific CD8 and CD4 T cell epitopes worldwide [10,11,13,15,20,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77] and aligning these with 107 published full-length polyprotein sequences of dengue virus isolates available from India. Here, CD4 is linked to dengue disease.