It could be useful to investigate the most frequent mutations with first-line molecular research, while the less frequent could be used as second-line research., we suggest the following genes as first-line molecular research: MYBPC3, MYH7, TNNT2, TNNI3 in the cases of genetic HCM; LMNA, TTN in the cases associated with DCM or DSP, DSG2, DSC2, RYR2, PKP2 for ACM. This evidence concerns the gene DSG2 and familial dilated cardiomyopathy.