Moreover, IL-8 might serve as a significant contributor to neuronal loss in Alzheimer’s disease by influencing the release of neurotoxic substances like matrix metalloproteinases (MMPs), and prompting the expression of proteins associated with neuronal cell death, including MMP-2, MMP-9, cyclin D1, and Bim [139]. Here, CXCL8 is linked to early-onset autosomal dominant Alzheimer disease.