TP53 and neoplasm: Additionally, sequencing based on a 637-gene panel identified four cases harboring somatic mutations in caretaker tumor-suppressor genes: TP53 (p.C238W, p.E271Q, p.C275Y, p.80fs, and p.P80L), BRCA1 (p.T367I), and BRCA2 (p.Q1187fs).