Since all three molecules play an important role in tumor infiltration and migration by affecting the intercellular adhesion capacity, we speculate that high GJA1 expression may affect the intercellular adhesion of KIRC tumors and thus reduce the metastatic capacity of KIRC, either by affecting the expression of CDH1 and CTNNB1 or by interfering with the ability of the two interactions between E-cadherin and β-catenin, which needs to be verified by further in-vitro experiments. The gene discussed is GJA1; the disease is neoplasm.