β-catenin/CTNNB1, as an intracellular scaffolding protein, could interact with adhesion molecules (E-cadherin/CDH1, N-cadherin/CDH2, VE-cadherin/CDH5, and α-catenins), involved in cell adhesion, intracellular signaling, and transcription, and its mutations have been identified in lung, liver, prostate, gastric, and bladder tumors, involved in the malignant progression of various cancers [61,62]. Here, CTNNB1 is linked to urinary bladder neoplasm.