A baseline AFP value ≥ 1000 ng/mL was found to be a risk factor also for DSS, both at the univariate and the multivariate regression analyses (HR 2.1; 95%CI 1.1–4.1; p = 0.019), along with tumor dimension ≥ 5 cm (HR 1.7; 95%CI 1.1–2.6; p = 0.012), Child–Pugh class B or C (HR 1.7; 95%CI 1.2–2.6; p = 0.007), BCLC stage A (vs. 0) (HR 1.9; 95%CI 1.2–2.9; p = 0.008), and malignant PVT (HR 2.2; 95%CI 1.1–4.5; p = 0.023). This evidence concerns the gene AFP and neoplasm.