AFP and hepatocellular carcinoma: At multivariate regression analysis, tumor dimension ≥ 5 cm (HR 2.3; 95%CI 1.5–3.8; p = 0.001), BCLC stage A (vs. 0) (HR 2.4; 95%CI 1.2–4.8; p = 0.011), HCC grade 3 (vs. 1–2) (HR 1.7; 95%CI 1.0–2.8; p = 0.003), and AFP ≥ 1000 ng/mL (HR 2.0; 95%CI 1.0–3.7; p = 0.038) (Figure 3b) were confirmed to be independent risk factors for recurrence (Table 3).