AFP ≥ 1000 ng/mL (HR 2.8; 95%CI 1.4–7.3; p = 0.005) and HCC grade 3 (vs. 1–2) (HR 2.8; 95%CI 1.0–8.1; p = 0.047) were correlated with an increased risk of LR. Here, AFP is linked to hepatocellular carcinoma.