At univariate analysis, tumor dimension ≥ 5 cm (HR 2.6; 95%CI 1.7–4.1; p < 0.001), BCLC stage A (vs. 0) (HR 2.2; 95%CI 1.2–4.0; p = 0.008), HCC grade 3 (vs. 1–2) (HR 1.4; 95%CI 0.8–2.4; p = 0.032), PVT (HR 2.4; 95%CI 1.5–3.7; p < 0.001), malignant PVT (HR 2.4; 95%CI 1.5–3.9; p < 0.001), and AFP ≥ 1000 ng/mL (HR 1.8; 95%CI 1.2–4.1; p = 0.021) were correlated with a reduced RFS. The gene discussed is AFP; the disease is hepatocellular carcinoma.