MAPK8 and Immunodeficiency: After their recognition as foreign, the immune response is induced through the signalling pathways Toll, IMD (immune deficiency), JAK/STAT (Janus kinase/signalling transducer and activator of transcription), JNK (Jun-N-terminal kinase) and MAPK (mitogen-activated protein kinase) [95,96,100,101,102,103,104,105,106].