The salivary factors present in R. prolixus, but not in Rhodnius colombiensis, that lyse epimastigotes of TcII, but not TcI [210], remain to be identified, but lysis of epimastigotes of T. cruzi in the stomach is only possible in established infections when the parasites have already colonized the small intestine and rectum [193]. The gene discussed is TCN2; the disease is infection.