In addition, this high 10-year cardiovascular risk for MDD patients was significantly associated with male sex, overweight, obesity, age ≥60 years, tobacco consumption, drinking alcohol, conventional cardiovascular risk factors, aspirin use, CRP levels ≥1 mg/L, restless legs syndrome alone or combined with periodic limb movement index ≥15/h, OSAS alone, and COMISA (Table 3). This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.