To study AD phenotypes in a 2D cell culture model using iPSC-derived neurons, a total of 6 iPSC lines were used, including two familial Alzheimer’s disease cell lines (FAD1 and FAD2) and their respective isogenic controls (IC1 and IC2) and two healthy controls (HC1 and HC2) (Table 1). Here, FANCD2 is linked to early-onset autosomal dominant Alzheimer disease.