SP4 and colonic neoplasm: Similar effects were described by Pathi et al., who observed an inhibitory effect on colon cancer cells’ (SW480, RKO, HT-29, and HCT-116) growth, downregulation of Sp-related genes (key genes for cell proliferation, angiogenesis, and cell survival), and a caspase-dependent proteolysis of Sp1, Sp3, and Sp4 [35].