However, in individuals with high CRP levels, the occurrence of this higher risk of developing hypertension and having hypertension-related complications may be explained by the activation of some deleterious pathophysiological mechanisms: alteration of the renin–angiotensin–aldosterone system, plaque remodelling, oxidative stress, endothelial dysfunction, opsonisation of oxidized LDL cholesterol, prothrombotic state, activation of complement cascade and vascular wall damage [5]. Here, REN is linked to endothelial dysfunction.